目前,对于线粒体在T细胞激活中的作用受到越来越多的关注,大多集中在糖酵解方面,本文作者提出线粒体来源的ROS(mitochondrial reactive oxygen species,mROS)在抗原特异性CD4+与CD8+T细胞激活中发挥重要作用。首先作者进行了多个离体实验。作者用丙酮酸钠代替培养基中的葡萄糖,发现CD3与CD28抗体激活,依然能够引起T细胞膜表面CD25及CD69增多和IL-2的mRNA升高。表明线粒体代谢能够维持T细胞的存活和激活。然而,阻断线粒体来源的ROS后,CD3与CD28抗体激 At present, the role of mitochondria in T cell activation is receiving more and more attention. Most of them are focused on glycolysis. The authors propose that mitochondrial reactive oxygen species (mROS) T cell activation plays an important role. First the author conducted a number of in vitro experiments. The authors used sodium pyruvate instead of glucose in the medium and found that activation of CD3 and CD28 antibodies still led to increased CD25 and CD69 and elevated mRNA of IL-2 on T cell membranes. Suggesting that mitochondrial metabolism can maintain T cell survival and activation. However, after blockade of mitochondrial-derived ROS, CD3 and CD28 antibodies are activated