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生物材料广泛应用于修复和再生医学,通过替代或再生恢复损伤组织的生理功能。矿化胶原是一种与天然骨组织具有相同化学成分和微观结构的复合材料,具有良好的生物相容性、生物可降解性、骨传导性和骨诱导性,在修复骨缺损、促进新骨形成方面具有很好的应用前景。巨噬细胞是免疫系统的重要组分,在维持机体的自身稳态、免疫监视、疾病进展和组织重建过程中发挥重要作用。任何生物材料植入体内后都会引发异物反应,巨噬细胞是参与异物反应的关键细胞。文章就生物材料与巨噬细胞的关系进行综述。
Biomaterials are widely used in repair and regenerative medicine to restore damaged tissues’ physiology through replacement or regeneration. Mineralized collagen is a natural bone tissue with the same chemical composition and microstructure of the composite material, has good biocompatibility, biodegradability, osteoconductivity and osteoinductivity in the repair of bone defects and promote new bone The formation of a good application prospects. Macrophages are important components of the immune system and play an important role in maintaining the body’s homeostasis, immune surveillance, disease progression and tissue remodeling. Implantation of any biomaterials will cause foreign body reaction, macrophages are the key cells involved in foreign body reaction. The article reviews the relationship between biological materials and macrophages.