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目的 :通过 2 0 1例地高辛的血药浓度的监测和分析 ,确定不同类型患者的地高辛治疗窗。方法 :荧光偏振免疫法测定地高辛浓度。结果 :地高辛治疗窗很窄 ,不同类型患者治疗窗不同 ,患者的心功能情况、年龄、肝肾功能及电解质平衡等因素对地高辛的血药浓度及疗效均有影响。结论 :地高辛的平均有效浓度为 ( 1.2 7± 0 .5 2 )ng/ml,平均无效浓度为 ( 0 .83± 0 .5 2 )ng/ml,平均中毒浓度为 ( 2 .1± 1.0 0 )ng/ml。肝肾功能正常且不伴有心律失常的患者地高辛的治疗窗为 ( 1.0 5± 0 .4 7)ng/ml。
OBJECTIVE: To determine and determine the therapeutic window of digoxin in different types of patients through the monitoring and analysis of blood concentration of 200 cases of digoxin. Methods: Fluorescence polarization immunoassay was used to determine digoxin concentration. Results: The therapeutic window of digoxin is very narrow. The treatment windows of different types of patients are different. The factors such as cardiac function, age, liver and kidney function and electrolyte balance affect digoxin plasma concentration and efficacy. CONCLUSION: The average effective concentration of digoxin is (1.2 7 ± 0.52) ng / ml, the average effective concentration is (0.83 ± 0.52) ng / ml and the average toxic concentration is (2.1 ± 1.0 0) ng / ml. The therapeutic window of digoxin was (1.05 ± 0.47) ng / ml in patients with normal liver function and without arrhythmia.