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抗精神病药物引起恶性症状群(简称NMS)的报道较少,由舒必利合并苯妥英钠所致NMS国内未见报道,现将我们遇到的1例报告如下。 患者 女性,47岁,已婚。癫痫大发作史7年,曾不规则服用安定、苯妥英钠等药。入院前2月,出现眠差,乱语、毁物等精神症状;10天前求治于他院,诊断为癫痫合并精神障碍,口服苯妥英钠0.1,tid,舒必利0.2tid,服药6天后出现高热(38.5℃～39.5℃),四肢躯干强直伴轻度震颤,不食、不语、不动;即停口服药,接受补液及庆大霉素等治疗3天,症状未见明显改善,并出现尿失禁,于87年7月2日入我院。
Antipsychotics cause malignant symptoms group (referred to as NMS) is less reported by sulpiride phenytoin due to NMS has not been reported in the country, we now encounter a report of the following. Patient female, 47 years old, married. Epilepsy epilepsy history of 7 years, irregular taking diazepam, phenytoin and other drugs. 2 months prior to admission, mental symptoms such as insomnia, gibberish, and ruin were found; 10 days prior to treatment in his hospital, diagnosis of epilepsy with mental disorders, oral phenytoin 0.1, tid, sulpiride 0.2tid, 38.5 ℃ ~ 39.5 ℃), limbs with mild tremor with mild tremor, no food, no words, do not move; that stop taking medication, receiving fluid and gentamicin treatment for 3 days, no significant improvement in symptoms, and urine Incontinence, on July 2, 1987 into our hospital.