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目的:观察伏格列波糖联合胰岛素治疗糖尿病肾病的疗效、不良反应及副作用。方法:60例2型糖尿病肾病患者随机分为两组:治疗组伏格列糖联合胰岛素30例和对照组单纯胰岛素30例,观察12周。结果:两组空腹血糖均显著下降,总有效率分别为93.3%和90%,两组相比下降幅度无统计学意义(P>0.05),伏格列波糖组降低餐后血糖高于对照组,总有效率分别为100%和86.7%(;p<0.01);两组均能明显降低糖化血红蛋白、微量白蛋白尿,治疗组优于对照组(p<0.05)。观察中对肝肾功能无影响,未见不良反应。结论:两组均能降低FBG、PPBG、GHAIC、MAU,但伏格列波糖组降低餐后2H血糖、糖化血红蛋白、尿微量蛋白更优于单纯胰岛素组。
Objective: To observe the curative effect, adverse reactions and side effects of voglibose and insulin in the treatment of diabetic nephropathy. Methods: Sixty diabetic patients with type 2 diabetic nephropathy were randomly divided into two groups: 30 patients in the treatment group and 30 insulin alone in the control group were treated with vasopressin and insulin for 12 weeks. Results: The fasting blood glucose decreased significantly in both groups with the total effective rates of 93.3% and 90%, respectively. There was no significant difference between the two groups (P> 0.05). The decrease of postprandial blood glucose in voglibose group was higher than that in control group Group, the total effective rate was 100% and 86.7% (; p <0.01); both groups can significantly reduce the HbA1c and microalbuminuria, the treatment group was better than the control group (p <0.05). No effect on liver and kidney function observed, no adverse reactions. CONCLUSION: FBG, PPBG, GHAIC and MAU can be decreased in both groups, but postprandial 2H blood glucose, glycosylated hemoglobin and urine microalbumin in voglibose group are better than those in simple insulin group.