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目的 :评价鼻咽癌咽旁间隙受侵面颈联合野照射长期疗效。方法 :从 1991年 1月至 1993年 12月 ,经 CT诊断咽旁间隙侵犯 ,实行面颈联合野照射的鼻咽癌病人 49例 ,按临床分期分层随机抽取同时期非面颈联合野照射 49例病人为对照组。 5年局控率、生存率计算用 Kaplan- Meier法 ,L og- rank作显著性检验。计数资料用 χ2检验。结果 :面颈联合野组生存率、局控率曲线图明显高于非面颈联合野组 (P <0 .0 5 ) ;茎突后区受侵面颈联野组生存率明显高于非面颈联合野组 (P= 0 .0 35 )。两组病人急性放射性反应以及放疗后遗症未见差异 (P >0 .0 5 )。结论 :鼻咽癌咽旁间隙受侵采用面颈联合野照射能提高生存率 ,急慢性放射性损伤未见增加
Objective: To evaluate the long-term efficacy of pharyngeal parapharyngeal space in nasopharyngeal carcinoma affected by irradiation of the face and neck. Methods: From January 1991 to December 1993, 49 cases of nasopharyngeal carcinoma were diagnosed as parapharyngeal space by CT. The patients were randomly divided into three groups according to clinical staging: non-face-neck combined field irradiation 49 patients as control group. 5-year local control rate, the survival rate calculated using Kaplan-Meier method, L og-rank for significant test. Counting data using χ2 test. Results: The survival rate and the rate of local control were significantly higher in the face-neck combined surgery group than in the non-face-neck combined operation group (P <0.05). The survival rate in the posterior styloid process group was significantly higher than that in the non- Cervical joint group (P = .035). There was no difference between acute radiotherapy and radiotherapy sequelae in the two groups (P> 0.05). Conclusion: Surgical treatment of nasopharyngeal parapharyngeal space can improve the survival rate of face-neck combined with field irradiation without any increase of acute and chronic radiation injury