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本实验用自行建立的多抗-单抗夹心ELISA检测了39例慢性乙肝病患者血清可溶性白介素2受体(sIL-2R)水平及其与血ALT、肝内单个核细胞浸润、肝细胞坏死之间的关系。结果显示慢性活动性肝炎(CAH)患者血清sIL-2R为672.49±409.62u/ml,慢性迁延性肝炎(CPH)为381.30±234.48u/ml,两者均显著高于正常对照和病人对照,并且sIL-2R水平高者,ALT也升高,肝细胞坏死程度高,肝内单个核细胞浸润也多。提示了sIL-2R为慢性乙肝病活动的指标之一,是机体免疫系统激活的标志之一。
In our experiment, the serum soluble interleukin-2 receptor (sIL-2R) level and serum ALT, intrahepatic mononuclear cell infiltration and hepatocyte necrosis in 39 patients with chronic hepatitis B were detected by multi-antibody- Relationship between. The results showed that serum sIL-2R was 672.49 ± 409.62u / ml in patients with chronic active hepatitis (CAH) and 381.30 ± 234.48u / ml in patients with chronic persistent hepatitis (CPH), both of which were significantly higher than those of normal controls and patients High levels of sIL-2R, ALT also increased, a high degree of hepatocellular necrosis, intrahepatic mononuclear cell infiltration and more. It is suggested that sIL-2R is one of the indicators of chronic hepatitis B activity and one of the signs of immune system activation.