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目的 :探讨乙型肝炎病毒 (HBV)感染患者发生消化性溃疡 (Pu)的主要因素及相互关系。方法 :采用酶联免疫吸咐试验检测血清中HBV标志物HBsAg ,同时通过胃黏膜尿素酶试验及组织学染色 ,进行Hp检查。用果胶铋、灭滴灵、四环素、雷尼替丁治疗 2周 ,治疗前后用内镜观察。结果 :HBsAg阴性患者Pu的发病率是2 1.5 9% (6 5 / 30 1) ,Hp感染率 38.36 % (115 / 30 1) ,Pu治愈率 81.5 4 % (5 3/ 6 5 ) ;HBsAg阳性患者Pu的发病率是 4 1.2 7% (2 6 / 6 3) ,Pu治愈率 4 6 .15 % (12 / 2 6 ) ,Hp感染率 5 6 .4 5 % (36 / 6 3) ,伴有门静脉高压的Pu占73.0 8% (19/ 2 6 )。结论 :HBV感染者Hp感染率高 ,Pu发病率高 ,治愈率低 ,Pu的发病机制可能与HBV对胃黏膜直接或间接损害等有关。
Objective: To investigate the main factors and their correlation of peptic ulcer (Pu) in patients with hepatitis B virus (HBV) infection. Methods: Serum HBV markers HBsAg were detected by enzyme-linked immunosorbent assay (Hp). Gastric mucosal urease test and histological staining were also performed. With bismuth pectin, metronidazole, tetracycline, ranitidine treatment for 2 weeks, before and after treatment with endoscopic observation. Results: The incidence of Pu in HBsAg-negative patients was 21.59% (6.5 / 30 1), Hp infection rate was 38.36% (115/30), Pu was 81.5% (5/65) The incidence of Pu was 42.7% (26/6 3), Pu was 46.5% (12/26), and Hp infection was 56.5% (36/63) Pu with portal hypertension accounted for 73.0% (19/26). Conclusion: The prevalence of Hp infection is high, the incidence of Pu is high, the cure rate is low, and the pathogenesis of Pu may be related to the direct or indirect damage of HBV to gastric mucosa.