论文部分内容阅读
蛋白酪氨酸磷酸酶非受体型22(protein tyrosine phos- phatase nonreceptor 22,PTPN22)是编码淋巴特异性蛋白酪氨酸磷酸酶(lymphoid protein tyrosine phosphatase,LYP)的基因,位于1号染色体短臂(1p13)。LYP是T细胞活化过程中的一种起调节作用的蛋白酪氨酸磷酸酶,相对分子质量约为110000,由C端富含脯氨酸的基序和N端磷酸酶活性区域组成,主要分布在淋巴细胞内。它通过C端一个命名为P1的富含脯氨酸基序与Csk蛋白酪氨酸激酶的SH3结构域连接,协同Csk抑制T细胞活化。最近研究发现PTPN22基因的一个单核苷酸多态(SNP),1858C转换为1858T(rs2476601),使密码子620编码的P1基序中一个高度保守的关键氨基酸精氨酸变为色氨酸(R620W),导致LYP和Csk不能结合。大
Protein tyrosine phos-phatase nonreceptor 22 (PTPN22) is a gene encoding lymphoid protein tyrosine phosphatase (LYP), located on chromosome 1 short arm (1p13). LYP is a regulatory T cell tyrosine phosphatase during T cell activation with a relative molecular mass of about 110,000 and is composed of a C-terminal proline-rich motif and an N-terminal phosphatase activity domain with a predominant distribution Within lymphocytes. It binds to the SH3 domain of the Csk protein tyrosine kinase through a C-terminal proline-rich motif designated P1, which inhibits T cell activation in conjunction with Csk. A recent study found that a single nucleotide polymorphism (SNP) of the PTPN22 gene, 1858C, was converted to 1858T (rs2476601) and a highly conserved key amino acid, arginine, in the P1 motif encoded by codon 620 was changed to tryptophan R620W), resulting in LYP and Csk can not be combined. Big