100多年前已发现肿瘤组织较正常组织富有血管。普遍认为这种血管反应只是炎症反应,并非肿瘤生长所必需,至于肿瘤是由已经存在的血管提供营养,还是由新生血管提供营养,一直存在争论。70年代Folkman最早提出肿瘤生长和转移依赖血管形成的假说。随着各种技术的改进和提高,一系列工作的完成,80年代这一观点才为越来越多的证据所证实,90年代血管生成的概念扩展到了全部肿瘤,并成为肿瘤研究的热点及肿瘤治疗的新策略。在原发性肝 More than 100 years ago, tumor tissue was found to be richer in blood vessels than normal tissues. It is generally believed that this vascular response is only an inflammatory reaction and is not required for tumor growth. It has been argued that whether the tumor is provided with nutrients from already existing blood vessels or nutrition is provided by new blood vessels. In the 1970s Folkman first proposed the hypothesis that tumor growth and metastasis depend on angiogenesis. With the improvement and improvement of various technologies and the completion of a series of work, this view of the 1980s was confirmed by more and more evidence. The concept of angiogenesis was extended to all tumors in the 1990s, and became a focus of cancer research. New strategies for cancer treatment. Primary liver