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目的:观察苯磺酸左旋氨氯地平和苯磺酸氨氯地平治疗高血压的降压效果与安全性差别。方法:将轻、中度高血压患者随机分两组,进行临床对照试验,观察基础血压与治疗后8周的血压变化及不良反应发生情况。结果:苯磺酸左旋氨氯地平和苯磺酸氨氯地平均能有效降低血压,8周有效率分别为84.3%和87.6%(P>0.05),苯磺酸左旋氨氯地平不良反应发生率低于苯磺酸氨氯地平。结论:苯磺酸左旋氨氯地平和苯磺酸氨氯地平均能有效控制血压,苯磺酸左旋氨氯地平的耐受性更高,且不良反应发生率较低。
Objective: To observe the antihypertensive effects and safety differences of levamlodipine besylate and amlodipine besylate in the treatment of hypertension. Methods: The patients with mild to moderate hypertension were randomly divided into two groups. The clinical control trial was conducted. The changes of blood pressure and adverse reactions were observed after 8 weeks of treatment. RESULTS: Both levamlodipine besylate and amlodipine besylate were effective in lowering blood pressure. The effective rates at 8 weeks were 84.3% and 87.6% (P> 0.05), and the incidence of adverse reactions of levamlodipine besylate Lower than amlodipine besylate. CONCLUSION: Both levamlodipine besylate and amlodipine besylate are effective in controlling blood pressure, levamlodipine besylate is more tolerated and the incidence of adverse reactions is lower.