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在女性生殖功能实现的复杂过程中,双调蛋白(amphiregulin,Areg)参与调控颗粒细胞的黄素化、卵母细胞减数分裂的恢复及调控卵子成熟、卵丘复合体的扩张及排卵,而且其表达水平与卵子的发育潜能密切相关。Areg与子宫内膜的容受性密切相关,可能参与到胚胎的着床过程中。Areg诱导合体滋养层细胞分泌大量绒毛膜促性腺激素(h CG),参与孕早期妊娠的维持。
In the complex process of female reproductive function, amphiregulin (Areg) is involved in the regulation of luteinization of granulosa cells, the recovery of oocyte meiosis, the regulation of egg maturation, the expansion and ovulation of cumulus complex, and its expression The level is closely related to the developmental potential of the egg. Areg is closely related to endometrial receptivity and may be involved in embryo implantation. Areg induced syncytiotrophoblast cells to secrete a large amount of hCG, which is involved in the maintenance of pregnancy during the first trimester.