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本文报道用捕捉法ELISA检测各型乙肝IgA型HBsAg循环免疫复合物。结果表明,慢性乙肝IgA型HBsAg循环免疫复合物检出率显著高于急性乙肝;在慢性乙肝中,IgA型HBsAg循环免疫复合物的出现与HBVe系统关系密切,主要存在于HBeAg阳性血清中,并与HBeAg滴度有关。故IgA型HBsAg循环免疫复合物可作为HBV慢性感染的血清诊断标志之一;也可作为反映HBV在增殖并有传播危险的标志之一。
This article reports the use of capture ELISA detection of various types of hepatitis B IgA type HBsAg circulating immune complexes. The results showed that the detection rate of chronic hepatitis B IgA-type HBsAg circulating immune complexes was significantly higher than that of acute hepatitis B. In chronic hepatitis B, the appearance of circulating immunocomplexes IgA type HBsAg was closely related to HBVe system, mainly in HBeAg-positive serum And HBeAg titer. Therefore IgA-type HBsAg circulating immune complexes can be used as a serum HBV diagnostic markers of chronic infection; also be used as a reflection of the proliferation of HBV and one of the signs of the risk of transmission.