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多胺是广泛存在于哺乳类组织细胞中的小分子有机化合物,参与细胞的生长和分化等重要的生理过程,也是肿瘤细胞的快速生长所必需。鸟氨酸脱羧酶(ornithine decarboxylase,ODC)是多胺合成代谢途径中的第一个限速酶,ODC活性的异常会引起包括肿瘤在内的一系列疾病的发生,由此该酶成为近年来研究的热点。简要综述了ODC与肿瘤关系的研究进展。
Polyamines are small organic compounds widely found in mammalian cells and are involved in important physiological processes such as cell growth and differentiation. They are also essential for the rapid growth of tumor cells. Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in the polyamine metabolic pathway. The abnormal ODC activity causes a series of diseases including tumors, Hot research. The research progress on the relationship between ODC and tumor was briefly reviewed.