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为了解肝硬化 (L C)患者血清可溶性细胞间粘附分子 - 1(s ICAM- 1)水平的变化及其与患者肝功能损伤的关系 ,用酶联免疫吸附法 (EL ISA)检测 17例正常人和 33例 L C患者的血清 s ICAM- 1。结果显示 ,L C患者血清 s ICAM- 1水平显著高于对照组 (HC) ,且在肝功能分级中 ,呈现 Child C>Child B>Child A的规律。相关分析显示 ,L C患者血清 s ICAM- 1与总胆红素 (TB)及谷丙转氨酶 (AL T)均呈明显正相关。提示 L C患者血清 s ICAM-1升高与肝细胞损伤有关 ,可反映 L C的严重程度。
To investigate the changes of serum soluble intercellular adhesion molecule-1 (s ICAM-1) levels and liver damage in patients with cirrhosis (LC), 17 normal subjects were detected by enzyme-linked immunosorbent assay (ELISA) Serum s ICAM-1 was measured in 33 patients and in LC. The results showed that serum ICAM-1 level in patients with L C was significantly higher than that in the control group (HC), and the law of Child C> Child B> Child A was presented in the classification of liver function. Correlation analysis showed that serum ICAM-1 levels were positively correlated with total bilirubin (TB) and alanine aminotransferase (ALT) in L C patients. These results suggest that elevated serum ICAM-1 in patients with L C is associated with hepatocellular injury and may reflect the severity of L C.