目的探讨2型糖尿病家系正常血糖一级亲属血清肿瘤坏死因子-α(TNF-α)的变化与胰岛素抵抗(IR)之间的关系。方法测定50例2型糖尿病家系正常血糖一级亲属(FDR)及30例健康人的TNF-α水平,计算胰岛素抵抗指数(HOMA-IR),分析两组之间的变化和联系。结果FDR组血清TNF-α水平明显高于对照组,多元逐步回归分析显示胰岛素抵抗指数(HOMA-IR)是主要影响因素。结论FDR人群存在早期胰岛素抵抗(IR),血清TNF-α是显示IR程度的重要指标。 Objective To investigate the relationship between the changes of serum tumor necrosis factor-α (TNF-α) and insulin resistance (IR) in first-degree relatives of type 2 diabetic families with normal blood sugar. Methods The levels of TNF-α in 50 first-degree relatives (FDR) of type 2 diabetic families and 30 normal controls were measured. HOMA-IR was calculated and the changes and associations between the two groups were analyzed. Results Serum levels of TNF-α in FDR group were significantly higher than those in control group. Hierarchical regression analysis showed that insulin resistance index (HOMA-IR) was the main influencing factor. Conclusion There is early insulin resistance (IR) in FDR population, and serum TNF-α is an important index to show the degree of IR.