论文部分内容阅读
δ-氨基乙酰丙酸(简称δ-ALA)是人体内合成血红蛋白的中间产物,即它在δ-氨基乙酰丙酸脱水酶的作用下生成合成血红素的中间体卟咀原。当过量的铅离子进入人体后,能抑制酶的活性,阻碍卟胆原的生成,而使δ-ALA在体内的含量增高,并经肾排出,故尿中δ-ALA含量增高。近些年来国内外推荐δ-ALA作铅中毒诊断指标,国家在铅中毒诊断指标中规定尿中δ-ALA含量不超过6.0毫克/升。但在近年来的实际工作中,我们见到无论接铅工人以及大多数铅中毒病例其尿中δ-ALA含量均明显低于这一数值。我们考虑可能是地区性差异所造成,因此我科于1979年6～7月间调查了201例正常人的尿中δ-ALA含量,推算本地区尿中δ-ALA含量的正常范围,为本地区开展铅中毒防治工作所用。一、调查对象及方法
δ-Aminolevulinic acid (δ-ALA) is an intermediate product of the synthetic hemoglobin in the human body. It is an intermediate of porphyrin that synthesizes heme in the presence of δ-aminolevulinic acid dehydratase. When excessive lead ions into the body, can inhibit the enzyme activity, hinder the production of porphyrin, and make the content of δ-ALA in the body increased and excreted by the kidneys, so the urine of δ-ALA increased. In recent years, domestic and international recommend δ-ALA as a diagnostic indicator of lead poisoning, the national diagnostic criteria in the lead poisoning provisions of urine δ-ALA content does not exceed 6.0 mg / l. However, in actual work in recent years, we have seen that the urinary δ-ALA content of both lead-free workers and most cases of lead poisoning is significantly lower than this value. We consider may be caused by regional differences, so our department in June to July 1979 survey of 201 normal subjects in the urinary δ-ALA content in the region to estimate the normal urine δ-ALA content, based on Areas for lead poisoning prevention and control work. First, the survey and methods