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目的 :观察胰岛素增敏剂二甲双胍改善 2型糖尿病胰岛素敏感性后对血压的影响。方法 :71例 2型糖尿病人口服二甲双胍 (格华止 ) 85 0 mg,qd-bid。治疗前后测定 BMI、血压、FBG、PBG、FINS、PINS,并按 HOMA模型计算胰岛素抵抗指数和胰岛素分泌指数。结果 :( 1)二甲双胍治疗 8周后 ,BMI治疗前后无显著性差异 ;血压治疗后明显下降 ,降压幅度达 ( 13.1± 4.97) /( 4 .2 2± 9.93) mm Hg,血压治疗前后有显著性差异。 ( 2 )治疗后 F BG、 PBG、 FINS均明显下降 ,治疗前后有显著性差异。 ( 3)治疗后 HOMA-IR下降 ,IAI升高 ,治疗前后有显著性差异 ,但 HOMA-IS、 FINS/FBG无显著性差异。结论 :二甲双胍治疗 2型糖尿病 ,在降低血糖、改善 IR的同时 ,伴有血压的明显下降
AIM: To observe the effect of metformin, an insulin sensitizer, on blood pressure after insulin sensitivity of type 2 diabetes mellitus. Methods: 71 patients with type 2 diabetes were treated with metformin (Gehua only) 85 0 mg qd-bid. BMI, blood pressure, FBG, PBG, FINS and PINS were measured before and after treatment. Insulin resistance index and insulin secretion index were calculated according to HOMA model. Results: (1) After 8 weeks of metformin treatment, there was no significant difference between before and after BMI treatment. The blood pressure decreased significantly after treatment (13.1 ± 4.97) / (4.2 ± 9.93) mm Hg Significant difference. (2) F BG, PBG, FINS were significantly decreased after treatment, there were significant differences before and after treatment. (3) After treatment, HOMA-IR decreased, IAI increased, before and after treatment there was a significant difference, but HOMA-IS, FINS / FBG no significant difference. CONCLUSION: Metformin treatment of type 2 diabetes mellitus can reduce blood glucose, improve IR and decrease blood pressure