目的探讨女性染色体多态性与供精人工授精妊娠结局的关系。方法对接受供精人工授精患者常规抽血行染色体检查,将发现有染色体多态的患者作为研究对象,与染色体正常群体对照,观察临床妊娠率、累积妊娠率和早期流产率。结果染色体多态性组与正常组比较,临床周期妊娠率(19.80%vs 19.66%),累积妊娠率(44.82%vs 41.77%),早期流产率(14.58%vs12.07%),均无统计学差异(P>0.05)。结论染色体多态性携带状态不影响供精人工授精患者的治疗结局。 Objective To investigate the relationship between female chromosome polymorphism and artificial pregnancy outcome. Methods The routine blood sampling was performed on the patients receiving artificial insemination, and the patients with chromosome polymorphism were investigated. Compared with the normal chromosomes, the clinical pregnancy rate, cumulative pregnancy rate and early miscarriage rate were observed. Results The rate of clinical pregnancy (19.80% vs 19.66%), the cumulative pregnancy rate (44.82% vs 41.77%) and the rate of early miscarriage (14.58% vs 12.07%) in the chromosomal polymorphism group were not significantly different from those in the normal group Difference (P> 0.05). Conclusion The status of chromosome polymorphism does not affect the therapeutic outcome of artificial insemination patients.