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选取2015年6月至2016年6月GDM患者30例为观察组,健康孕妇30例为对照组,结果观察组孕中期感染及总感染发生率较对照组明显提高,(P<0.05);在孕妇外周血中,观察组CD~+_4、CD~+_4/CD~+_8、CD~+_(16)CD~+_(56)表达水平较对照组明显降低,CD+8表达水平明显明细提高,(P<0.05);观察组IgE水平较对照组明显提高,IgG水平明显降低,(P<0.05);在脐静脉血中,观察组CD~+_3、CD~+_4、CD~+_4/CD~+_8、CD~+_(16)CD~+_(56)较对照组明显降低,(P<0.05);观察组IgM、IgE、IgG水平与对照组比较,(P>0.05)。结论妊娠期糖尿病将增加感染发生率,扰乱体液免疫细胞及免疫功能,还将损伤新生儿出生时的细胞免疫功能。
Thirty patients with GDM were selected as the observation group and 30 healthy pregnant women as the control group from June 2015 to June 2016. The results showed that the infection rate in the second trimester and the total infection rate in the observation group were significantly higher than those in the control group (P <0.05) The levels of CD ~ + _4, CD ~ + _4 / CD ~ + _8 and CD ~ + _ (16) CD ~ + _ (56) in the peripheral blood of pregnant women were significantly lower than those in the control group (P <0.05). The level of IgE in the observation group was significantly higher than that in the control group, and the level of IgG was significantly decreased (P <0.05). In the umbilical vein blood, the levels of CD_3, CD_4, (P <0.05). Compared with control group, the levels of CD_ (+) CD_ (+) CD_ 0.05). Conclusion Gestational diabetes mellitus will increase the incidence of infection, disrupt humoral immune cells and immune function, and will also impair the cellular immune function at birth.