Aztreonam(AZT)是一种合成的单环内酰胺抗生素。对多数革蓝氏阴性菌、包括肠杆菌属、绿脓杆菌均有抗菌作用。对革蓝氏阳性菌及厌氧菌无效。本品血浓度高,蛋白结合率56％,血浆半衰期1.7小时,在体内不被代谢,由肾小球滤过,给药量的65％以原形从尿中排出。本文主要评价AZT治疗46例(50例次)严重细菌性感染的临床疗效、耐受性和毒性。 Aztreonam (AZT) is a synthetic monobactam antibiotic. For most Gram-negative bacteria, including Enterobacter, Pseudomonas aeruginosa have antibacterial effects. Gram-positive bacteria and anaerobic bacteria invalid. This product high blood concentration, protein binding rate of 56%, plasma half-life of 1.7 hours, not metabolized in the body by the glomerular filtration, the amount of 65% of the prototype discharged from the urine. This article mainly evaluates the clinical efficacy, tolerability and toxicity of 46 cases (50 cases) of severe bacterial infections treated with AZT.