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目的:探讨尿液中激肽原1(KNG1)在评估妊娠期高血压疾病严重程度中的临床意义。方法:选取妊娠期高血压、轻度子痫前期、重度子痫前期孕妇及正常健康足月妊娠女性各20例,分别检测其尿液中的KNG1浓度,并与平均动脉压和24 h尿蛋白进行相关性分析。结果:轻度子痫前期组孕妇尿液中KNG1浓度和正常妊娠组比较,差异无统计学意义(P>0.05);而妊娠期高血压组和重度子痫前期组孕妇尿液中KNG1浓度相对于正常妊娠组显著下降,差异有统计学意义(P<0.05),且重度子痫前期组孕妇尿液中KNG1浓度显著低于轻度子痫前期组(P<0.05)。Pearson相关分析显示:尿液中KNG1浓度与平均动脉压呈显著负相关(r=-0.351,P=0.001),但与24 h尿蛋白无相关性(r=-0.136,P=0.301)。结论:尿液中KNG1含量可以作为一项灵敏和可靠指标来评估妊娠期高血压疾病的病情,且在一定程度上反映疾病的严重程度。
Objective: To investigate the clinical significance of urinary kallikrein 1 (KNG1) in assessing the severity of hypertensive disorder complicating pregnancy. Methods: Twenty pregnant women with gestational hypertension, mild preeclampsia, severe preeclampsia and normal healthy full-term pregnancy women were enrolled in this study. The concentrations of KNG1 in urine were measured and compared with mean arterial pressure and 24-hour urinary protein Conduct correlation analysis. Results: There was no significant difference in urine concentration of KNG1 between pregnant women with mild preeclampsia and normal pregnancy (P> 0.05), while the levels of KNG1 in urine of pregnant women with severe preeclampsia and severe preeclampsia The levels of KNG1 in urine of pregnant women with severe preeclampsia were significantly lower than those of mild preeclampsia (P <0.05). Pearson correlation analysis showed that the concentration of KNG1 in urine had a significant negative correlation with mean arterial pressure (r = -0.351, P = 0.001), but no correlation with 24 h urine protein (r = -0.136, P = 0.301). Conclusion: The content of KNG1 in urine can be used as a sensitive and reliable indicator to evaluate the condition of hypertensive disorders in pregnancy, and to some extent reflect the severity of the disease.