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目的探讨复发性卵巢上皮癌的治疗方法及预后。方法回顾性分析复发性卵巢上皮癌67例,分为三组:手术+化疗组22例,单纯化疗组38例,未治疗组7例。结果手术+化疗组、单纯化疗组的中位生存时间分别为17、15个月,其生存率相比较,相互间无显著性差异(P>0.05);未治疗组(中位生存时间5个月)与其他两组相比较,有显著性差异(P<0.05)。残存癌灶≤2cm的中位生存时间为23个月,而>2cm者为9个月,两组的生存率有显著性差异(P<0.05)。停药时间>6个月后复发者中位生存时间为18个月,≤6个月者为5个月,两组的生存率有显著性差异(P<0.05)。结论个体化、分阶段的综合疗法,对治疗复发性卵巢癌有一定效果,满意的二次肿瘤细胞减灭术和二线化疗,可改善患者预后。
Objective To investigate the treatment and prognosis of recurrent epithelial ovarian cancer. Methods Retrospective analysis of 67 cases of recurrent epithelial ovarian cancer, divided into three groups: surgery + chemotherapy group of 22 cases, chemotherapy alone group 38 cases, untreated group of 7 cases. Results The median survival time of operation + chemotherapy group and chemotherapy alone group was 17 and 15 months, respectively. There was no significant difference between the two groups in the survival rate (P> 0.05). The median survival time in untreated group was 5 Month) compared with the other two groups, there was a significant difference (P <0.05). The median survival time of residual tumor less than or equal to 2cm was 23 months, while those over> 2cm were 9 months. The survival rates of two groups were significantly different (P <0.05). The median survival time after relapse for 6 months was 18 months and 5 months ≤ 6 months. The survival rates were significantly different between the two groups (P <0.05). Conclusion Individualized and phased comprehensive therapy have some effects on the treatment of recurrent ovarian cancer. Satisfactory secondary cytoreductive surgery and second-line chemotherapy can improve the prognosis of patients.