1970年日本武田化学工业公司报道了抗绿脓杆菌半合成青霉素——磺苄青霉素的合成专利,并于1972年投入工业生产。磺苄青霉素具有稳定性强、可于室温保存等优点,但对绿脓杆菌的活性不强,对于严重感染需用较大剂量。近年武田公司又合成了一系列具有a-磺酸基 1970 Japan Takeda Chemical Industry Company reported synthetic anti-Pseudomonas aeruginosa semi-synthetic penicillin-penicillin, and in 1972 put into industrial production. Methyl penicillin has strong stability, can be stored at room temperature and other advantages, but the activity of Pseudomonas aeruginosa is not strong, the need for larger doses for severe infections. In recent years Takeda company has synthesized a series of a-sulfonic acid group