原发性胼胝体变性(MBD)是一种比较少见的胼胝体脱髓鞘病,多见于慢性酒精中毒或营养不良者。虽发病率低、临床表现缺乏特异性,但随着CT及MR技术的发展和普及,早期诊断已成为可能。本文报道我院急诊科2015年收治的1例原发性胼胝体变性的临床表现、影像学特点、诊疗过程进行分析,并复习该病的国内外文献,探讨在MBD的诊疗过程中需重视的问题。 Primary corpus callosum degeneration (MBD) is a relatively rare demyelinating disease of the corpus callosum, more common in chronic alcoholism or malnutrition. Although the incidence is low, the clinical manifestations of the lack of specificity, but with the development and popularity of CT and MR technology, early diagnosis has become possible. This article reports the clinical manifestations, imaging features, diagnosis and treatment of 1 case of primary corpus callosum degeneration treated in emergency department of our hospital in 2015, and reviews the domestic and foreign literature on the disease to explore the issues that should be emphasized in the treatment of MBD .