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青年胃印戒细胞癌是临床上预后较差的恶性肿瘤。为了研究该肿瘤患者的免疫状态及应用γδT淋巴细胞治疗可能性，4例青年胃印戒细胞癌、6例正常人外周血作了免疫细胞表型分析及TNF、IL－6检测。并对4例患者采用γδT细胞／IL－2过继免疫治疗（ACIT），观察细胞免疫动态变化。结果表明：4例青年胃印戒细胞癌患者外周血CD、CD、CD／CD比值均低于正常组，TNF、IL-6水平均高于正常组；γδT细胞治疗后，外周血CD、CD、CD／CD比值均升高。随访12～25月未见转移、复发。
Young stomach signet ring cell carcinoma is a malignant tumor with a poor prognosis. In order to study the immune status of this tumor patient and the possibility of using γδT lymphocyte therapy, immunophenotypic analysis of phenotypic and TNF and IL-6 were performed in 4 cases of gastric signet-ring cell carcinoma and 6 normal controls. Four patients were treated with γδT cells/IL-2 adoptive immunotherapy (ACIT) to observe the dynamic changes of cellular immunity. The results showed that the ratios of CD, CD, CD/CD in peripheral blood of 4 patients with gastric signet ring cell carcinoma were lower than those in normal group, and the levels of TNF and IL-6 were higher than those in normal group; CD and CD in peripheral blood were detected after γδT cell treatment. The ratio of CD/CD increased. No metastasis or recurrence occurred during follow-up from 12 to 25 months.