目的了解辽宁省流行性脑脊髓膜炎(流脑)菌群变化和人群抗体水平。方法流脑菌培养、鉴定用巧克力培养基于(36±0.5)℃、5%CO2培养;用ELISA法检测抗体。结果8个年龄组901份血清样本检测结果表明,辽宁省的流脑病例多数由流脑A群引起,也有流脑C群病例存在,病例接触者携带流脑菌以A群为主,占72%。人群抗体水平A群抗体保护率为76.25%,平均抗体含量为11.78μg/ml。C群抗体保护率为53.39%,平均抗体含量为3.73μg/ml。A群C群间抗体水平差异有统计学意义。各年龄组间抗体水平差异有统计学意义。结论辽宁省流脑发病仍以婴幼儿为主,有向大年龄组迁移趋势,存在菌群变异可能,人群抗体水平不足以阻止C群流脑流行,需加强人群免疫,加强疾病监测,采取措施,保护人群健康。 Objective To understand the changes of population and population antibody of epidemic cerebrospinal meningitis in Liaoning Province. Methods Mycobacterium melobacter was cultured and identified with chocolate culture medium at (36 ± 0.5) ℃ and 5% CO2. Antibody was detected by ELISA. Results The results of 901 serum samples from 8 age groups showed that most of the cases of meningitis in Liaoning Province were caused by meningococcal group A and there were cases of meningococcal group C, %. Population antibody level Group A antibody protection rate was 76.25%, the average antibody content of 11.78μg / ml. Group C antibody protection rate was 53.39%, the average antibody content of 3.73μg / ml. There were significant differences in antibody levels between group A and group C. Antibody levels in all age groups were significantly different. Conclusion The prevalence of meningitis in Liaoning Province is still mainly infants and young children. It tends to migrate to older age groups, and there may be variation in flora. The level of antibody in population is not enough to prevent the epidemic of group C meningococci. It is necessary to strengthen population immunity and strengthen disease surveillance and take measures , To protect the health of the population.