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本文使用低分子肝素(Fragmin)作为抗凝剂一次性给药进行血液透析.观察了26例患者294次血液透析的疗效。结果显示,使用 Fragmin 抗凝时,透析器重复使用平均4.5次,未见明显透析器内及透析管路凝血;用药前后凝血酶原时间、凝血酶原活动度、部分凝血活酶时间、血红蛋白、血小板计数无明显变化(P>0.05);每次用药前后血浆抗因子 Xa 活性变化显著(P<0.001);未发现严重出血病例。本文的结论是透析开始时,一次性给予 Fragmin 行 HD 抗凝,安全有效、简单方便。
This article uses low molecular weight heparin (Fragmin) as anticoagulant for a one-time administration of hemodialysis observed in 26 patients 294 hemodialysis curative effect. The results showed that when Fragmin anticoagulation was used, the dialyzer was repeatedly used for an average of 4.5 times, and there was no obvious coagulation in the dialyzer and dialysis line. Prothrombin time, prothrombin activity, partial thromboplastin time, hemoglobin, There was no significant change in platelet count (P> 0.05). The change of plasma anti-factor Xa activity before and after treatment was significant (P <0.001). No severe bleeding was found. The conclusion of this paper is that when dialysis is started, Fragmin HD anticoagulation is given once and safely, which is simple and convenient.