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目的 :为穿心莲有效成分血清药物化学的研究提供基础研究资料。方法 :以穿心莲内酯 (Andrographolide)为指标性成分 ,应用反相HPLC法 ,测定口服穿心莲药材提取物后 ,家兔血清中穿心莲内酯含量的变化。结果 :口服给药后 ,在测定的时间段内 (0～ 8h) ,Andrographolide在血清中均有分布 ,给药后 1小时达到峰值。 结论 :Andrographolide血药浓度变化曲线 ,可能对穿心莲二萜内酯类成分含药血清制备具有指导意义。
Objective : To provide basic research data for the study of serum drug chemistry of active ingredients of Andrographis paniculata. METHODS: Andrographolide was used as the index component and reverse-phase HPLC method was used to determine the changes of andrographolide content in serum of rabbits after oral administration of Andrographis paniculata extract. RESULTS: After oral administration, Andrographolide was distributed in the serum during the determined time period (0 to 8 h) and peaked at 1 h after administration. Conclusion : The curve of plasma concentration of Andrographolide may be useful for the preparation of serum containing diterpene lactones in Andrographolide.