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肉瘤１８０（Ｓ_１８０）细胞注入到小鼠腹腔中制得荷瘤鼠模型，用新城鸡瘟病毒（ＮＤＶ）Ｂ１株治疗，观察１个月。青年鼠（７周龄）生存率达７６．７％，而老龄鼠（１年龄）和未经治疗的青年鼠均１００％死亡。病毒在Ｓ１８０腹水中基本不繁殖。进一步观察发现，经ＮＤＶ治疗的荷瘤鼠，７周龄鼠血清干扰素增高、ＮＫ细胞活性增强，而１年龄鼠中则未观察到此现象。７周龄鼠治疗后第４天可检测出抗病毒抗体，第８天时效价达１：１６００。用ＮＤＶ体外感染巨噬细胞也可诱生出较高浓度干扰素。结果提示，干扰素增高、ＮＫ细胞活性增强可能与抗肿瘤疗效有关，而抗病毒抗体与疗效间的关系，尚需进一步研究。
Sarcoma 180 (S_180) cells were injected into the abdominal cavity of the mice to obtain a tumor-bearing mouse model. They were treated with Newcastle disease virus (NDV) B1 strain and observed for one month. The survival rate of young rats (7 weeks old) reached 76.7%, while 100% of old rats (1 year old) and untreated young mice died. The virus does not multiply in the ascites of S180. Further observations revealed that in NDV-treated tumor-bearing mice, serum interferon was increased and NK cell activity was enhanced in 7-week-old mice, but this phenomenon was not observed in 1 year-old mice. Antiviral antibodies were detected on the 4th day after treatment in 7-week-old rats, and the titer reached 1:1600 on the 8th day. Infection of macrophages with NDV in vitro can also induce higher concentrations of interferon. The results suggest that increased interferon and enhanced NK cell activity may be related to anti-tumor efficacy, and the relationship between anti-viral antibodies and efficacy needs further study.