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【目的】探讨混合细胞型肝癌（cHCC‐CC）临床病理特征及分析其预后影响因素。【方法】收集本院1995年6月至2012年5月经手术切除或由肝穿刺活检并经病理确诊为cHCC‐CC的90例患者，其中86例随访资料完整者被纳入本次研究对象。回顾性分析其临床病理特征及其预后影响因素。【结果】86例cHCC‐CC患者中有81例术前误诊为肝细胞癌，术后病理诊断为CHCC‐CC ；男性患者占绝大多数，男女比例约为：5∶1。患者有肝硬化82．6％（71／86），乙肝病毒感染史74．4％（64／86），术前甲胎蛋白（AFP）阳性17．4％（15／86）。随访存活者22例，死亡56例，失访8例，随访率为90．7％，生存时间为3．2～47个月。术后1、3、5年累积生存率分别为53．5％（46／86）、20．9％（18／86）、7．0％（6／86），中位生存期7个月。【结论】CHCC‐CC在临床上罕见，缺乏临床表现特异性，诊断困难，大多数患者就诊已属晚期，主要依靠术后病理学诊断，恶性程度高，预后差。目前，根治性手术治疗是唯一改善患者预后的有效措施。“,”Objective]To explore the clinicopathological features and prognosis of 86 patients with com‐bined hepatocellular carcinoma and cholangiocarcinoma (cHCC‐CC ) .[Methods]A total of 90 patients with pathologically confirmed cHCC‐CC were recruited from our hospital from June 1995 to May 2012 .And the clinicopathological and follow‐up data were available for 86 cHCC‐CC patients .Their clinicopathological char‐acteristics and prognostic factors were analyzed .[Results]Among them ,81 cases were misdiagnosed as prima‐ry liver cancer .The ratio of male to female was 5 :1 .The concurrent conditions were liver cirrhosis (71/86 , 82 .6% ) ,history of hepatitis b virus (64/86 ,74 .4% ) and preoperative positive alpha‐fetoprotein (15/86 , 17 .4% ) .The outcomes were survival ( n =22) ,death ( n =56) and loss to follow‐up ( n=8) .The follow‐up rate was 90 .7% .And the median survival time was 7(3 .2~47) months .The 1 ,3 ,5‐year cumulative sur‐vival rates were 53 .5% (46/86) ,20 .9% (18/86) and 7 .0% (6/86) respectively .[Conclusion]cHCC‐CC is rare clinically with a high malignant degree and a poor prognosis .Due to a lack of specific manifestations ,it is often difficult to diagnose .A definite diagnosis is dependent on postoperative pathological confirmation .At present ,radical surgery is the only effective measure for improved patient prognosis .