曲尼司特是一种过敏递质阻滞剂,化学名为N-(3’,4’-二甲氧基肉桂酰)氨茴酸。口服2-3 h后血药浓度达到峰值,半衰期为8.6 h,相对生物利用度约为93%。它最初主要应用于Ⅰ型变态反应疾病如支气管哮喘和变态反应性鼻炎的治疗,后来发现其亦具有抗Ⅱ、Ⅲ、Ⅳ型变态反应的作用,并能用于多种皮肤病的治疗。近来,文献报道它在心血管疾病治疗上也有一定的作用,本文就其作用机制及其在心血管疾病中的应用作一综述。 Tranilast is an allergic neurotransmitter blocker with the chemical name N- (3 ’, 4’-dimethoxycinnamoyl) anthranilic acid. After 2-3 hours of oral administration of plasma concentration reached its peak, the half-life of 8.6 h, the relative bioavailability of about 93%. It was initially mainly used in the treatment of type I allergic diseases such as bronchial asthma and allergic rhinitis. Later on, it was also found to have anti-type II, III and IV allergy effects and could be used for the treatment of various skin diseases. Recently, it has been reported in the literature that it also plays a role in the treatment of cardiovascular diseases. This article reviews its mechanism of action and its application in cardiovascular diseases.