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为了解增殖细胞核抗原（ＰＣＮＡ）在胃肿瘤中的表达及其临床意义，应用免疫组化技术（ＡＢＣ法），对胃肿瘤（胃腺瘤性息肉１０例，胃癌９４例）组织切片中ＰＣＮＡ含量进行半定量检测。结果：①胃粘膜不同病理状态下ＰＣＮＡ指数差异有极显著性意义（Ｐ＜０．０１）；②ＰＣＮＡ指数与患者的性别和年龄无关（Ｐ＞０．０５），而与肿瘤的生长方式、组织类型、浆膜层受侵与否、淋巴结转移与否和临床分期关系密切（Ｐ＜０．０５）；③ＰＣＮＡ指数与胃癌的预后密切相关（Ｐ＜０．０５），弱级（Ⅰ～Ⅱ级）表达的患者预后好。由此表明，ＰＣＮＡ检测可作为判断胃癌生物学行为和预后的良好指标之一。
To investigate the expression and clinical significance of proliferating cell nuclear antigen (PCNA) in gastric cancer, immunohistochemical technique (ABC method) was used to detect the PCNA content in gastric tumors (10 cases of gastric adenomatous polyps and 94 cases of gastric cancer). Semi-quantitative detection. Results: 1 There was a significant difference in PCNA index under different pathological conditions of the gastric mucosa (P<0.01); 2 PCNA index had nothing to do with the gender and age of the patients (P>0.05), but with the growth pattern and organization of the tumor. Whether the type, serosal layer was invaded or not, lymph node metastasis or not was closely related to clinical stage (P<0.05); 3PCNA index was closely related to the prognosis of gastric cancer (P<0.05), weak grade (Grade I-II) The patients with the expression have a good prognosis. This shows that PCNA detection can be used as a good indicator to judge biological behavior and prognosis of gastric cancer.