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本文作者以小鼠为实验材料探讨生殖细胞及胚胎阶段适应性反应规律及其对子代的影响。结果表明:50mGyX射线单次照射小鼠生殖细胞可降低相继大剂量辐射诱导显性致死发生率,亚急性(50mGy×4)和慢性照射雄性小鼠生殖细胞可产生明显的细胞遣传适应性反应;但对子代生殖细胞,骨髓细胞和DNA损伤(UDS)无明显影响,说明,低剂量辐射在生殖细胞诱导的适应性反应不能传递给子代个体,与生殖细胞阶段不同,低剂量慢性照射小鼠胚胎可使成熟小鼠对电离辐射诱发染色体畸变具有明显的抗性。
The authors used mice as experimental materials to investigate the adaptive response of germ cells and embryos and their effects on offspring. The results showed that single irradiation of mouse germ cells with 50mGy X-rays could reduce the incidence of dominant lethality induced by successive large doses of radiation. Subacute (50mGy × 4) and chronic irradiation of male mice germ cells could produce significant cell deportation adaptive response , But had no significant effect on germ cells, bone marrow cells and DNA damage (UDS) in progeny, indicating that the adaptive response induced by low dose radiation in germ cells can not be transmitted to offspring individuals. Different from germ cell stage, low dose chronic exposure Mouse embryos can make mature mice have obvious resistance to chromosome aberration induced by ionizing radiation.