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采用酶联免疫吸附实验、放射免疫测定和间接免疫荧光等方法,现察了58例外科腹内感染患者血浆内毒素(LPS)、肿瘤坏死因子(TNF)及前列腺E_2(PGE_2)在病程中的演变规律及对机体的损伤作用。分析了通里攻下法的应用对上述病理生理学改变和患者预后的影响。结果表明,治疗组异常指标的改善早于对照组,TNF的检出率和含量下降较快,内毒素减毒率提高和并发症发生率减低。并探讨了通里攻下法药理效应产生的理论基础和可能的作用机理。
Using enzyme-linked immunosorbent assays, radioimmunoassays, and indirect immunofluorescence, 58 patients with intra-abdominal infections were examined for plasma endotoxin (LPS), tumor necrosis factor (TNF), and prostate E2 (PGE_2) during the course of disease. Evolution and damage to the body. The influence of the Tongli attack method on the above-mentioned pathophysiological changes and patient’s prognosis was analyzed. The results showed that the improvement of the abnormal index in the treatment group was earlier than that in the control group. The detection rate and content of TNF decreased rapidly, the endotoxin attenuation rate increased, and the incidence of complications decreased. The theoretical basis and possible mechanism of the pharmacological effects produced by the Tongli attack method were discussed.