高血压是一复杂疾病,环境和基因因素决定其最终的表型。大量研究提示,高血压患者体内存在β_2-肾上腺素能受体(β_2-AR)调节的改变,这些变动可能与β_2-AR编码区单核苷酸改变有关,其中16、27位点基因的改变很常见。本文对β_2-AR多态性参与高血压发病的病理生理学机制进行探讨。 Hypertension is a complex disease, environmental and genetic factors determine the final phenotype. A large number of studies suggest that β 2 -adrenoceptor (β 2 -AR) regulatory changes exist in patients with hypertension, and these changes may be related to single nucleotide changes inβ_2-AR coding region, in which the changes of 16,27 very common. In this paper, β_2-AR polymorphisms involved in the pathophysiology of hypertension pathogenesis are discussed.