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目的继续研究人乳头瘤病毒与肺癌的病因关系。方法采用多重聚合酶链反应 (PCR)技术 ,对 7种肺组织进行HPV8、HPV18及HPV35型检测。结果在鳞癌及其邻近鳞状化生上皮中 ,HPV18和HPV35的检出率无明显差异 ,肺鳞癌和腺癌中 ,两者亦无明显差异 ,在肺鳞癌和正常支气管粘膜中HPV18的检出率却有显著差异 (P <0 0 1)。结论HPV18和HPV35型感染与肺鳞癌和腺癌的发生有关 ,HPV18更具危险性
Objective To continue studying the etiology of human papillomavirus (HPV) and lung cancer. Methods Polymerase chain reaction (PCR) was used to detect HPV8, HPV18 and HPV35 in 7 kinds of lung tissues. Results In squamous cell carcinoma and its adjacent squamous metaplasia, there was no significant difference in the detection rate of HPV18 and HPV35 between lung squamous cell carcinoma and adenocarcinoma, and there was no significant difference between the two. In squamous cell carcinoma and normal bronchial mucosa, HPV18 The detection rate was significantly different (P <0.01). Conclusion HPV18 and HPV35 infection are associated with the occurrence of squamous cell carcinoma and adenocarcinoma, and HPV18 is more dangerous