PVC膜离子选择电极,不但可选取的活性材料广泛,而且使用方便,易于微型化,故发展较快。钠离子选择膜电极也有所发展,其中以1,1,1-三[1’-(2’-氧杂-4’-氧代-5’-氮杂-5’-甲基)十二烷基]丙烷(以下称为化合物Ⅵ)为活性物质的钠离子选择膜电极,其选择性可与玻璃钠离子选择电极相媲美,并且已制成微型电极,用来测定细胞内钠离子的活度,克服了微型玻璃电极的缺点。关于化合物Ⅵ的合成。文献[1]中已简略报导了以重氮乙酸乙酯为初始原料的合成方法。基于我国的实际情况,我们从甘氨酸出发,经六步反应,且各步均以较好的产率合成了化合物Ⅵ。本文还对合成方法和数步产物的性 PVC membrane ion selective electrode, not only can choose a wide range of active materials, and easy to use, easy to miniaturization, so the rapid development. Sodium ion selective membrane electrodes have also been developed in which 1,1,1-tris [1 ’- (2’-oxa-4’-oxo-5’-aza-5’-methyl) dodecane (Hereinafter referred to as Compound VI) as an active material, the selectivity of which is comparable to that of glass sodium ion selective electrodes and has been fabricated as a miniature electrode for measuring the activity of intracellular sodium ions , To overcome the shortcomings of the micro-glass electrode. About compound Ⅵ synthesis. The synthesis method using diazoacetic acid ethyl ester as the starting material has been briefly reported in [1]. Based on the actual situation in our country, we proceeded from glycine through six steps, and synthesized compounds Ⅵ with good yields in all steps. This article also on the synthesis method and the nature of several products