【摘 要】
:
Semi-batch crystallization of 7-amino-desacetoxycephalosporanic acid (7-ADCA) is a complicated pro-cess, in which agglomeration occurs together with nucleation
【机 构】
:
The State R&D Center of Industrial Crystallization
论文部分内容阅读
Semi-batch crystallization of 7-amino-desacetoxycephalosporanic acid (7-ADCA) is a complicated pro-cess, in which agglomeration occurs together with nucleation and crystal growth. To systematically study such aprocess, experiments were conducted to estimate the crystallization thermodynamics and kinetics, and then theprocess was simulated by a numerical method. The application of Monte Carlo concept in the algorithm to describeagglomeration event offers an alternative approach of solving the population balance, the intrinsic simplicity of whichallows us to investigate several mechanisms and include several internal coordinates in the analysis. Furthermore,present study may be a valuable paradigm for other semi-batch crystallization processes.
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