7-氨基去乙酰氧基头孢菌素半间歇反应结晶过程

来源 :中国化学工程学报 | 被引量 : 0次 | 上传用户:faith661
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Semi-batch crystallization of 7-amino-desacetoxycephalosporanic acid (7-ADCA) is a complicated pro-cess, in which agglomeration occurs together with nucleation and crystal growth. To systematically study such aprocess, experiments were conducted to estimate the crystallization thermodynamics and kinetics, and then theprocess was simulated by a numerical method. The application of Monte Carlo concept in the algorithm to describeagglomeration event offers an alternative approach of solving the population balance, the intrinsic simplicity of whichallows us to investigate several mechanisms and include several internal coordinates in the analysis. Furthermore,present study may be a valuable paradigm for other semi-batch crystallization processes.
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