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目的:探讨高原性高血压患者B型脑钠肽(BNP)与血管紧张素系统的相关性。方法:入选50例高原性高血压患者测血浆BNP浓度,RIA法测定血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮浓度,并与30例健康自愿体检者作对照。结果:各级高原性高血压组(1级19例、2级20例、3级11例)血浆BNP、PRA、AngⅡ浓度显著高于对照组(P<0.01),氧饱和度低于对照组。结论:高原性高血压患者血压与血浆BNP、PRA、AngⅡ的浓度变化存在正相关,氧饱和度较对照组均有不同程度降低,提示高原性高血压患者血BNP升高与高原地区氧饱和度、肾素血管紧张素醛固酮系统密切相关。
Objective: To investigate the relationship between type B brain natriuretic peptide (BNP) and angiotensin system in patients with high altitude essential hypertension. Methods: Plasma BNP levels were measured in 50 patients with high altitude essential hypertension. The plasma renin activity (PRA), angiotensin Ⅱ (AngⅡ) and aldosterone concentrations were measured by RIA and compared with 30 healthy volunteers. Results: Plasma BNP, PRA and AngⅡ concentrations were significantly higher in patients with high altitude essential hypertension at all stages (19 in grade 1, 20 in grade 2 and 11 in grade 3) (P <0.01), oxygen saturation was lower than that in control group . Conclusions: There is a positive correlation between blood pressure and plasma BNP, PRA and AngⅡ concentrations in patients with high altitude hypertension. The oxygen saturation is lower than that of the control group, suggesting that elevated blood BNP and altitude oxygen saturation , Renin angiotensin aldosterone system is closely related.