论文部分内容阅读
目的通过对常山县引入轮状病毒(RV)疫苗前后RV抗原检测结果进行分析,了解A群RV感染情况的变迁,为临床诊疗提供依据。方法采用免疫层析双抗体夹心法检测常山县2011—2014年门诊及住院的6月龄~3岁腹泻患儿的RV抗原,分析4年间RV抗原检出率的变化。结果 2011—2014年本地门诊及住院的6月龄~3岁腹泻患儿的RV抗原检出率呈下降趋势(P<0.01)。对535例患儿病前RV疫苗免疫史的回顾调查结果显示,389例疫苗接种儿童的RV阳性率为2.31%,明显低于未接种RV疫苗的11.64%(P<0.01)。结论常山县门诊及住院的6月龄~3岁患儿RV感染呈下降趋势,但2014年仍有5.00%阳性率,应继续加强疫苗接种,对腹泻患儿进行常规RV抗原检测。
Objective To analyze the detection results of RV antigen before and after the introduction of rotavirus (RV) vaccine in Changshan County so as to understand the changes of RV infection in group A and provide the basis for clinical diagnosis and treatment. Methods Immunochromatography double antibody sandwich method was used to detect RV antigen in children aged 6 months to 3 years old in outpatients and inpatients from 2011 to 2014 in Changshan County. The detection rate of RV antigen in four years was analyzed. Results The detection rate of RV antigen in children aged 6 months to 3 years old in outpatients and inpatients showed a decreasing trend from 2011 to 2014 (P <0.01). A retrospective review of the immunization history of 535 pre-existing RV vaccines showed that the positive rate of RV in 389 vaccinated children was 2.31%, significantly lower than that of the unvaccinated RV vaccine (11.64%, P <0.01). Conclusions RV infection in children aged 6 months to 3 years in outpatient department and hospitalized in Changshan County is on the decline. However, there is still a positive rate of 5.00% in 2014. Vaccination should be continued to detect routine RV antigen in children with diarrhea.