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目的研究X线修复交叉互补基因1(XRCC1)遗传位点399多态性对中国人群原发性肝细胞癌的相关性。方法通过检索PubMed和CNKI等数据库,收集有关XRCC1多态性与原发性肝细胞癌关联的6篇相互独立研究文献,对1072原发肝癌病例和1400健康人进行Meta分析和关联研究。结果通过XRCC1 399位点所有数据研究,经等位基因病例对照,等位基因G的OR值(95%CI)为1.23(0.96,1.59),=0.11;与基因型AA比较,基因型AG+GG的OR值(95%CI)为1.33(0.92,1.92),=0.13,说明该位点多态性对原发性肝癌发生不是危险因子。通过层次分析,在乙肝或黄曲霉素暴露所诱导的那80%的肝癌患者中,该位点是原发性肝癌发生的危险因子在未知病因所诱导的肝癌患者中,该位点未显示对原发性肝癌发生危险作用。结论中国人群XRCC1基因遗传位点399与乙肝或黄曲霉素暴露所诱导的肝癌发生相关。
Objective To study the association of polymorphism of XRCC1 locus 399 with primary hepatocellular carcinoma in Chinese population. Methods We searched 6 databases of PubMed and CNKI to collect 6 independent research articles about the relationship between XRCC1 polymorphism and primary hepatocellular carcinoma. Meta-analysis and association study were performed on 1072 primary liver cancer cases and 1400 healthy individuals. Results The allele G (OR 95% CI) was 1.23 (0.96,1.59), = 0.11 according to all the data of XRCC1 399 locus. Compared with genotype AA, the genotype AG + The odds ratio (95% CI) of GG was 1.33 (0.92,1.92), = 0.13, indicating that the polymorphism of this locus was not a risk factor for the development of primary liver cancer. By level analysis, this site is a risk factor for the development of primary liver cancer in 80% of hepatocellular carcinoma patients induced by hepatitis B or aflatoxin exposure, which is not shown in patients with hepatocellular carcinoma induced by unknown etiology Hazard of primary liver cancer. Conclusion The genetic loci of XRCC1 gene 399 in Chinese population are associated with the development of hepatocellular carcinoma induced by hepatitis B or aflatoxin exposure.