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目的 观察乳头溢液CEA、β2-MG和Fer含量对乳腺癌的诊断价值。方法 应用放射免疫分析法,对110例乳头溢液患者乳头溢液中癌胚抗原(CEA)、β2-微球蛋白(β2-MG)与铁蛋白(Fer)含量进行了检测,同时对乳头溢液进行乳腺脱落细胞学检查。结果 乳腺癌患者乳头溢液中CEA、β2-MG和Fer含量明显高于正常对照组和乳腺良性病变组(P<0.01),血清中CEA、β2-MG和Fer含量虽然明显高于正常对照组及乳腺良性病变组,但由于与乳腺癌组与乳腺良性病变组之间存在较多的交叉性,将乳头溢液与血清中CEA、β2-MG和Fer含量联合进行检测,并不能提高乳腺癌的阳性诊断率。110例乳头溢液标本进行脱落细胞学检查,34例(87.2)找到腺癌细胞。结论 检测乳头溢液中CEA、β2-MG和Fer含量对于诊断乳腺癌具有重要价值。
Objective To observe the diagnostic value of CEA, β2-MG and Fer in nipple discharge in breast cancer. Methods The contents of carcinoembryonic antigen (CEA), β2-microglobulin (β2-MG) and ferritin (Fer) in 110 patients with nipple discharge were detected by radioimmunoassay, Liquid for breast cytology. Results The levels of CEA, β2-MG and Fer in breast nipple discharge in breast cancer patients were significantly higher than those in normal control group and benign breast lesions group (P <0.01). The levels of CEA, β2-MG and Fer in serum were significantly higher than those in normal control group And breast benign lesion group, but because of the more cross with the breast cancer group and benign breast lesions group, the combination of nipple discharge and serum CEA, β2-MG and Fer content detection, and can not improve breast cancer The positive diagnostic rate. 110 cases of nipple discharge specimens for exfoliative cytology, 34 cases (87.2) to find the adenocarcinoma cells. Conclusion Detection of CEA, β2-MG and Fer in nipple discharge is of great value in the diagnosis of breast cancer.