目的：观察兰索拉唑联合克拉霉素、阿莫西林根除幽门螺杆菌及对溃疡愈合的效果。方法：对经胃镜确诊为消化性溃疡的病人进行幽门螺杆菌检测，确认为阳性者４６例给予兰索拉唑３０ｍｇ每日１次口服，共２周；克拉霉素０２ｇ每日３次口服；阿莫西林０５ｇ每日３次口服，共４周，停药４周后复查胃镜及幽门螺杆菌检查。结果：胃溃疡愈合率７７８％；十二指肠溃疡愈合率９２８％；幽门螺杆菌根除率胃溃疡为８３３％，十二指肠溃疡为８８９％，副作用发生率为２１８％。结论：兰索拉唑联合克拉霉素、阿莫西林是安全有效的治疗幽门螺杆菌感染消化性溃疡的方案 Objective: To observe the effect of lansoprazole combined with clarithromycin and amoxicillin in the eradication of Helicobacter pylori and ulcer healing. Methods: Helicobacter pylori was detected in patients diagnosed as peptic ulcer by gastroscope. 46 cases were given lansoprazole 30mg once daily for 2 weeks. Clarithromycin 0.2g 3 times a day Oral; amoxicillin 0  5g 3 times a day orally for 4 weeks, 4 weeks after withdrawal of gastroscopy and Helicobacter pylori examination. Results: The healing rate of gastric ulcer was 778%. The healing rate of duodenal ulcer was 928%. The rate of Helicobacter pylori eradication was 833%, the duodenal ulcer was 889%. The incidence of side effects 2  18%. Conclusions: Lansoprazole combined with clarithromycin and amoxicillin is safe and effective in the treatment of peptic ulcer due to Helicobacter pylori infection