论文部分内容阅读
目的探讨CK7、CK20、MUC6、维甲酸受体(RARα)在各类结直肠锯齿状病变中的表达及鉴别意义。方法应用免疫组化方法检测CK7、CK20、MUC6、RARα在44例增生性息肉(HP),45例传统锯齿状腺瘤(TSA),11例广基锯齿状腺瘤(SSA)中的表达情况,并以结直肠管状腺瘤、腺癌及正常黏膜组织作为对照。结果 CK7阳性率HP为45.4%,SSA为36.4%,TSA为22.2%。CK20在结直肠各组病变中阳性率均较高,表达无差异。统计学分析显示,HP与TSA比较CK7的阳性率差异显著。MUC6的阳性率在SSA中为36.4%,HP中为4.5%,TSA中为11.1%。RARα的阳性率在HP中为38.6%,SSA中为81.8%,TSA中为62.2%。统计学分析RARα的阳性强度在HP和CRC中差异显著,在各型锯齿状病变间则差异不显著。结论 CK7(+)对鉴别HP和TSA有一定意义;MUC6(+)有助于SSA的确诊;RARα在锯齿状病变和结直肠腺癌组织中的阳性强度比正常结直肠黏膜组织减弱,但对各类锯齿状病变的鉴别意义不大。
Objective To investigate the expression and differential significance of CK7, CK20, MUC6 and retinoic acid receptor (RARα) in various types of colorectal serrated lesions. Methods The expressions of CK7, CK20, MUC6 and RARα in 44 cases of proliferative polyps (HP), 45 cases of traditional serrated adenomas (TSA) and 11 cases of wide-base serrated adenomas (SSA) were detected by immunohistochemistry , And colorectal tubular adenoma, adenocarcinoma and normal mucosa as a control. Results The positive rate of CK7 was 45.4% for HP, 36.4% for SSA and 22.2% for TSA. The positive rates of CK20 in the colorectal lesions were higher, but there was no difference in expression. Statistical analysis showed that there was a significant difference in the positive rate of CK7 between HP and TSA. The positive rate of MUC6 was 36.4% in SSA, 4.5% in HP and 11.1% in TSA. The positive rate of RARα was 38.6% in HP, 81.8% in SSA, and 62.2% in TSA. Statistical analysis RARα positive intensity in HP and CRC significant difference, in all types of serrated lesions was not significantly different. Conclusions CK7 (+) is of certain significance for the differential diagnosis of HP and TSA. MUC6 (+) is helpful for the diagnosis of SSA. The positive rate of RARα in serrated lesions and colorectal adenocarcinoma is weaker than that of normal colorectal mucosa, All kinds of serrated lesions of little significance.