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目的 探讨纤溶酶对脑梗死急性期患者活化部分凝血活酶时间(APTT)?血浆凝血酶原时间(PT)与血液流变学的影响?方法 选取我院2017年1月至2020年12月收治的150例脑梗死急性期患者作为研究对象,分为观察组(纤溶酶+常规治疗)和对照组(常规治疗)各75例,比较两组患者的治疗效果?结果 观察组患者的APTT[(28.19±2.04)svs.(25.37±1.57)s,t=9.487]?PT[(12.35±1.07)svs.(10.86±1.43)s,t=7.225]?简式Fugl-Meyer运动功能评“,”Objective To investigate the effects of plasmin on activated partial thromboplastin time (APTT), plasma prothrombin time (PT) and hemorheology in patients with acute cerebral infarction. Methods 150 patients with acute cerebral infarction treated in our hospital from January 2017 to December 2020 were divided into observation group (plasmin + routine treatment) and control group (routine treatment), with 75 cases in each group. The therapeutic eff of the two groups were compared. Results APTT [(28.19±2.04) s vs. (25.37±1.57) s, t =9.487], PT [(12.35±1.07) s vs. (10.86±1.43) s, t =7.225] and simple Fugl-Meyer motor function score [(85.54±6.22) vs. (80.23±4.06), t =6.205] in the observation group were higher than those in the control group (P <0.05). The whole blood viscosity [(3.86±0.50) mPa/s vs. (4.34±0.54) mPa/s in the observation group after treatment, t =5.648],plasma viscosity [(1.45±0.33) mPa/s vs. (1.60 ± 0.39) mPa/s, t =2.543] and NIHSS score [6.41±2.05) vs. (8.28±1.97), t =5.696] were lower than those in the control group (P <0.05). Conclusion In the clinical treatment of acute cerebral infarction, the application of plasmin has a positive impact on the rapid and good improvement of APTT, PT and hemorheology.