[Objective]To optimize the extraction process of total flavonoids from Elaeagnus angustifolia of Ningxia.[Method]Based on single factor test,effects of extraction temperature,ethanol concentration,extraction duration and solid-liquid ratio on the yield rate of total flavonoids from Elaeagnus angustifolia were investigated by orthogonal design.[Result] The optimum conditions were as follows:extraction temperature of 80 ℃,extraction duration of 1 h,60% ethanol as extractant,solid-liquid ratio of 1∶18.Under the optimal conditions,the yield rate of total flavonoids reached as high as 3.070 mg/g.[Conclusion] This study provides scientific basis for improving the medical efficacy and further development of Elaeagnus angustifolia. [Objective] To optimize the extraction process of total flavonoids from Elaeagnus angustifolia of Ningxia. [Method] Based on single factor test, effects of extraction temperature, ethanol concentration, extraction duration and solid-liquid ratio on yield yield of total flavonoids from Elaeagnus [Result] The optimum conditions were as follows: extraction temperature of 80 ° C, extraction duration of 1 h, 60% ethanol as extractant, solid-liquid ratio of 1:18. Undertake the optimal conditions, the yield rate of total flavonoids reached as high as 3.070 mg / g. [Conclusion] This study provides scientific basis for improving the medical efficacy and further development of Elaeagnus angustifolia.