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目的探讨定君生联合两性霉素B对妊娠期外阴阴道假丝酵母菌病的临床疗效,为妊娠期的安全用药提供参考。方法选取116例妊娠期外阴阴道假丝酵母菌病患者,随机分为对照组和治疗组,对照组单纯给予两性霉素B,治疗组在对照组的基础上给予定君生,分别于治疗后10、30和60 d对患者的临床疗效和阴道分泌物情况进行评价。结果治疗后60 d治疗组总有效率显著高于对照组(94.82%vs 82.76%,P<0.05);治疗后60d治疗组复发例数明显少于对照组(12.07%vs 29.31%,P<0.05)。结论定君生联合两性霉素B对妊娠期外阴阴道假丝酵母菌病的临床疗效显著,且其治疗效果维持时间长,可较好的预防患者复发。
Objective To investigate the clinical efficacy of Dingjun combined with amphotericin B in the treatment of vulvovaginal candidiasis during pregnancy and to provide a reference for the safe medication during pregnancy. Methods One hundred and sixty-six cases of vulvovaginal candidiasis during pregnancy were randomly divided into control group and treatment group. The control group was given amphotericin B only. On the basis of the control group, the treatment group was given Ding Jun students. After treatment, The clinical efficacy and vaginal discharge of the patients were evaluated at 10, 30 and 60 days. Results After 60 days of treatment, the total effective rate of the treatment group was significantly higher than that of the control group (94.82% vs 82.76%, P <0.05). The number of relapse cases in the 60 days after treatment was significantly less than that in the control group (12.07% vs 29.31%, P <0.05 ). Conclusion Dingjun Health combined with amphotericin B on pregnancy vulvovaginal candidiasis clinical significant effect, and the treatment effect of maintaining a long time, can better prevent the recurrence of patients.