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目的 研究血清白蛋白 （ＡＬＢ） 及血浆凝血酶原活动度 （ＰＴＡ） 与肝组织病理损害的关系。方法 用酶速率法测定１３５ 例经病理证实的慢性肝炎、肝炎肝硬变及重型肝炎患者的ＡＬＢ， 用比浊法测定其ＰＴＡ。结果 在慢性肝炎轻度至中度， ＰＴＡ 较ＡＬＢ下降的百分率更高（Ｐ＜ ０．０１）； 随肝组织炎症程度及纤维化程度的加重， 各项指标均逐渐下降（Ｐ＜ ０．００１）， ＡＬＢ与ＰＴＡ 间相关系数为０．７２０（Ｐ＜ ０．００１）。结论 ＰＴＡ较ＡＬＢ更好地反映肝脏合成功能、储备功能，能更准确地反映肝脏的病理损害程度， 它们均与肝脏病理损害呈明显负相关
Objective To investigate the relationship between serum albumin (ALB) and plasma prothrombin activity (PTA) and pathological changes of liver tissue. Methods The enzymatic rate method was used to determine the albuminuria (ALB) of 135 patients with pathologically confirmed chronic hepatitis, hepatitis cirrhosis and severe hepatitis. The PTA was measured by turbidimetry. Results The percentage of PTA was lower than that of ALB in mild to moderate chronic hepatitis (P <0.01), and all indicators decreased gradually with the degree of inflammation and the degree of fibrosis (P <0.001) ), The correlation coefficient between ALB and PTA was 0.720 (P <0.001). Conclusion PTA better reflects ALB synthesis function and reserve function than ALB, which can more accurately reflect the degree of liver pathological damage, which are negatively correlated with liver pathological damage