论文部分内容阅读
目的:探究抗结核药所致药物性肝炎应用多烯磷脂酰胆碱治疗的疗效。方法:选取2011年10月-2013年10月在本院诊治的抗结核药所致药物性肝炎患者96例,按照随机数字表法将患者分成两组,每组48例,对照组予肌苷、肝泰乐和门冬氨酸钾镁治疗,研究组联合多烯磷脂酰胆碱治疗,分析两组临床疗效、症状改善和肝功能的相关指标变化情况。结果:治疗后研究组的总有效率为93.75%,对照组为79.17%,两组比较差异有统计学意义(P<0.05)。研究组尿黄、皮肤巩膜的黄染分别为6.25%、10.42%,对照组分别为22.92%、29.17%,两组比较差异均有统计学意义(P<0.05)。同时研究组相关AST、ALT和TBIL等肝功能指标均低于对照组,两组比较差异均有统计学意义(P<0.05)。结论:对抗结核药所致药物性肝炎患者,予多烯磷脂酰胆碱联合治疗效果显著,症状和肝功能相关指标明显改善,具有一定的临床应用和研究价值。
Objective: To investigate the therapeutic effect of polyene phosphatidylcholine on drug-induced hepatitis induced by anti-TB drugs. Methods: Ninety-six patients with drug-induced hepatitis induced by antituberculosis drugs in our hospital from October 2011 to October 2013 were divided into two groups according to the random number table method, 48 cases in each group. The control group was treated with inosine , Gilectin and potassium-magnesium aspartate treatment, the study group combined polyene phosphatidylcholine treatment, analysis of two groups of clinical efficacy, symptoms and liver function changes related indicators. Results: After treatment, the total effective rate was 93.75% in the study group and 79.17% in the control group. The difference between the two groups was statistically significant (P <0.05). The study group of yellow urine, skin sclera of yellow dye were 6.25%, 10.42%, respectively, the control group were 22.92%, 29.17%, the difference between the two groups were statistically significant (P <0.05). At the same time, the indexes of liver function, such as AST, ALT and TBIL, in the study group were lower than those in the control group. There were significant differences between the two groups (P <0.05). Conclusions: The combination therapy of polyene phosphatidylcholine and the treatment of drug-induced hepatitis caused by tuberculosis drugs has obvious effect, and the indexes related to the symptoms and liver function are obviously improved, which has certain clinical application and research value.